RETRACTED ARTICLE: Ponicidin treatment attenuates ovalbumin-induced allergic rhinitis in mice and RBL-2H3 cell line models

Allergic rhinitis (AR) is the chronic type of that arises due to hypersensitivity response. It caused by nasal mucosa inflammation and becomes a social burden in later stages. Ponicidin diterpenoid isolated from herbs like Rabdosia rubescens possesses anti-inflammatory properties. Hence, present study was designed analyze effects against AR using ovalbumin (OVA)-sensitized murine model also reveal mode action Ponicidin. Mice were sensitized with 75 μg OVA 2 mg aluminium hydroxide 200 μl buffer for 0, 7, 14, 21 days provoke AR. treatment given diet at different doses (5, 10, 15 mg/kg). The nose-rubbing numbers noted carefully. levels histamine, inflammatory cytokines, NF‐κB DNA binding assay assessed kits. cell counts performed hemocytometer. lung tissues analysed microscopically identify histological changes. viability control treated RBL-2H3 cells analyzed MTT assay. β-hexosaminidase activity assayed kit. Results showed significantly attenuated rubbing OVA-induced mice suppressing histamine release, secretion cytokines. effect comparable standard drug dexamethasone. In also, decreased Thus, it can be inferred emerge as an effective management